The use of recombinant FSH in the treatment of infertility associated with a high level of sperm DNA fragmentation.

Introduction. Male infertility, caused by a high level of sperm DNA fragmentation, remains one the significant problems reproductive medicine. One methods to overcome it may be use recombinant follicle-stimulating hormone (FSH), but results studies on this issue are ambiguous. The purpose literature review is systematize publications issue. Materials and methods. search, analysis systematization in databases PubMed, eLibrary.ru, Clinicaltrials.gov were carried out using keywords «male infertility», «sperm fragmentation», «treatment», «follicle stimulating hormone», «FSH». Seventy six selected included review. Results discussion. integrity genetic material prerequisites for formation normal embryo. Its damage occurs two main ways: induction apoptosis direct reactive oxygen species. FSH stimulates spermatogenesis also prevents spermatozoa through activation protein kinase B/AKT. Also regulates chromatin packing increases ability bind hyaluronic acid. infertile men led an improvement morphological parameters spermogram, motility, decrease however, data obtained difficult compare due heterogeneity patient groups study, lack standardization studying fragmentation its different threshold values. Conclusions. Therapy with promising overcoming infertility patients fragmentation. published does not allow draw unambiguous conclusions regarding effect spermatozoa. Future need strict inclusion criteria, such as thresholds pharmacogenetic study.